Optimizing LC-MS Separations of mAbs using a BioResolve SCX mAb Column and IonHance CX-MS pH Concentrates

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…

Application Note Accelerating Charge Variant Analysis of Biotherapeutics with the BioAccord™ System Robert E. Birdsall, Brooke M. Koshel, Ying Qing Yu Waters Corporation Abstract Ion Exchange Chromatography (IEX) is a valuable technique given its ability to resolve product/process related charge…

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[ APPLICATION NOTE ] Practical Considerations for Optimizing MS Quality during IEX-MS Andrew Schmudlach and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Improve mass spectral quality MS cleanliness is a surprisingly overlooked aspect of protein LC-MS…