Spatial Metabolomics by Mass Spectrometry Imaging using Desorption Electrospray Ionization (DESI)

SPATIAL MAPPING OF LIPIDS AND NEUROTRANSMITTER IN RAT BRAIN SECTIONS USING DESI ION MOBILITY MASS SPECTROMETRY Roy Martin1, Anthony J. Midey1, Hernando J. Olivos1, Emmanuelle Claude2, Bindesh Shrestha1 1 Waters Corporation, Milford, MA, USA and 2 Waters Corporation, Wimslow, United…

[ APPLICATION NOTEBOOK ] MS IMAGING AND AMBIENT IONIZATION-MS FOR METABOLOMICS AND LIPIDOMICS 1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245EN TABLE OF CONTENTS 3 Introduction 4 Biomarker Discovery Directly from…

Utility of Desorption Electrospray Ionization (DESI) for Mass Spectrometry Imaging Emmanuelle Claude and Emrys Jones G OA L DESI imaging provides effective and meaningful To describe the DESI imaging technique as applied to mass spectrometry imaging using time-of-flight (TOF) mass…

QUANTITATIVE IMAGING MASS SPECTROMETRY OF ENDOGENOUS METABOLITES USING IN-LINE INTERNAL STANDARDS AND STABLE ISOTOPE LABELED MIMETIC MODEL Bindesh Shrestha,1 Khaja Muneeruddin,2 Scott A. Shaffer2 1 Waters Corporation, Beverly, MA 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School…