SPATIAL MAPPING OF LIPIDS AND NEUROTRANSMITTER IN RAT BRAIN SECTIONS USING DESI ION MOBILITY MASS SPECTROMETRY

Spatial Metabolomics by Mass Spectrometry Imaging using Desorption Electrospray Ionization (DESI) Bindesh Shrestha, Anthony Midey, Hernando Olivos, and Emrys Jones Waters Corporation, Milford, MA, USA INTRODUCTION • Spatial mapping of metabolites can increase our understanding of the biological functions of…

[ APPLICATION NOTEBOOK ] MS IMAGING AND AMBIENT IONIZATION-MS FOR METABOLOMICS AND LIPIDOMICS 1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245EN TABLE OF CONTENTS 3 Introduction 4 Biomarker Discovery Directly from…

Application Note High-Performance DESI-MSI using a DESI XS Xevo™ TQ Absolute XR system for Sensitive and Specific Targeted Imaging of Small Molecules in Tissue Sections Emmanuelle Claude Waters Corporation, Wilmslow, United Kingdom Published on September 23, 2025 Abstract Desorption Electrospray…

COLLISION CROSS SECTION ENABLED DESI ION MOBILITY MASS SPECTROMETRY IMAGING Anthony J. Midey, Hernando J. Olivos, and Bindesh Shrestha Waters Corp., Beverly, MA INTRODUCTION Mass spectrometry imaging (MSI) determines the localization of compounds on samples, including tissue sections and drug…