INVESTIGATING PRIMARY AND HIGHER-ORDER PROTEIN STRUCTURE ANALYSIS USING A NOVEL CYCLIC ION MOBILITY ENABLED QTOF PLATFORM

In-Depth Versatile Characterization of Aspartic Acid Isomers via a Cyclic Ion Mobility Mass Spectrometry (cIMS) Samantha Ippoliti1; Brad J. Williams1, Dale Cooper-Shepherd2, Ying Qing Yu1, Weibin Chen1, Barbara Sullivan1, James I. Langridge2 1Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow,…

Application Note Deep Characterization of Aspartic Acid Isomerism Using High-Resolution Cyclic™ Ion Mobility and Electron-Capture Dissociation Samantha Ippoliti, Brad Williams, Dale Cooper-Shepherd Waters Corporation, United States Published on January 06, 2026 Application Brief This is an Application Brief and does…

Waters Cyclic IMS P20 Mass Spectrometer Insight—revealed, not inferred. Insight— revealed, not inferred Biological systems are inherently complex, and answering today’s research questions requires tools that can reveal that complexity with clarity. The Waters™ Cyclic™ IMS P20 Mass Spectrometer enables…

TANDEM ION MOBILITY COUPLED WITH MASS SPECTROMETRY FOR GAS PHASE UNFOLDING STUDIES Dale A. Cooper-Shepherd1, LeRoy B. Martin2, Martin Palmer1, James I. Langridge1 1 Waters Corporation, Wilmslow, Cheshire, UK, SK9 4 AX, 2Waters Corporation, Beverly, MA OVERVIEW  The cyclic…