Deep Characterization of Aspartic Acid Isomerism Using High-Resolution Cyclic™ Ion Mobility and Electron-Capture Dissociation

In-Depth Versatile Characterization of Aspartic Acid Isomers via a Cyclic Ion Mobility Mass Spectrometry (cIMS) Samantha Ippoliti1; Brad J. Williams1, Dale Cooper-Shepherd2, Ying Qing Yu1, Weibin Chen1, Barbara Sullivan1, James I. Langridge2 1Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow,…

Application Note Electron Capture Dissociation in Combination With High Performance Cyclic Ion Mobility Separation for Detailed Protein Studies Dale Cooper-Shepherd Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract Electron capture dissociation (ECD)…

Application Note Separating and Identifying Site-Specific Isomeric Amino Acids in GLP-1 Receptor Agonists on the Cyclic™ IMS P20 Mass Spectrometer Dale Cooper Shepherd, Isabella Jones, Emma Marsden-Edwards Waters Corporation, Wilmslow, United Kingdom Published on July 06, 2026 Abstract Isomeric amino…

Application Note Biopharma Identification of Amino Acid Isomers Using Electron Capture Dissociation in the Agilent 6545XT AdvanceBio LC/Q-TOF System Authors Rachel Franklin and Joseph Meeuwsen Agilent Technologies, Inc. Abstract Accurately determining the amino acid sequence is crucial for understanding a…