Adding Mass Selective Detection to Improve Analytical Sensitivity and Maximize Confidence in Results for Impurity Profiling by UHPLC

Application Note Pharma & Biopharma Using Self-Aware Agilent InfinityLab LC/MSD iQ to Measure Trace-Level Impurities in a Brand Versus Generic Medication Author Kyle Covert, PhD Agilent Technologies, Inc. Abstract This study presents a method for comparison of related impurities in…

High-Resolution Sampling 2D-LC for Pharmaceutical Impurity Analysis Detection of Impurities Hidden Under the API Peak at Relevant Levels Application Note Small Molecule Pharmaceuticals and Generics Authors Abstract Susanne Stephan and Sonja Krieger The analysis of impurities in low concentrations relative…

Characterization of Synthetic Peptide Drug and Impurities using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography/Mass Spectrometry (LC/MS) 1D Column Column Agilent AdvanceBio Peptide Mapping 120Å, 2.1 x 150mm, 2.7 µm 0.4 mL/min Injection volume 20 μL Column temperature A) B)…

Application Note Biopharmaceuticals Peptide Drug Stability Analysis Using Agilent InfinityLab LC/MSD and OpenLab CDS Deconvolution Author Chae-Young Ryu Agilent Technologies, Inc. Abstract The Federal Drug Administration (FDA) abbreviated new drug application (ANDA) guidelines advise qualitative and quantitative management of peptide-related…