Highly sensitive quantitative estimation of genotoxic impurities from API and drug formulation using LC/MS/MS

[ APPLICATION NOTE ] High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug Product using the Waters ACQUITY UPLC I-Class/Xevo TQ-XS Tandem Quadrupole Mass Spectrometer Mary Trudeau Lame and Lindsay Hatch Waters Corporation, Milford, MA, USA APPLICATION…

Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Mary Trudeau Lame , Lindsay Hatch, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA 2. UPLC Chromatographic Separation of Nitrosamine Impurities…

Application Note Pharmaceutical Determination of Nitrosamines in Active Pharmaceutical Ingredients High flexibility and performance at lowest cost using the Agilent 1260 Infinity II Prime LC with the Agilent Ultivo LC/TQ for LC/MS analysis Author Edgar Naegele Agilent Technologies, Inc. Abstract…

The Use of the ACQUITY QDa Detector for a Selective, Sensitive, and Robust Quantitative Method for a Potential Genotoxic Impurity Janet Hammond Waters Corporation, Wilmslow, UK A P P L I C AT I O N B E N E…