High-Resolution Charge Variant Analysis for Top-Selling Monoclonal Antibody Therapeutics Using a Linear pH Gradient Separation Platform

APPLICATION NOTE 21778 Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies Authors Amy Farrell, Craig Jakes, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…

See your protein therapeutics in high resolution Bio LC Columns Contents 2 Introduction to monoclonal antibody (mAb) characterization 3 Affinity titer determination 4 Aggregate separation 5 Charge variant analysis 6 Oxidation variant analysis 11 Antibody drug conjugates (ADCs) analysis 12…

BioLC columns Connected chromatography solutions BioLC columns and accessories Introduction Your complete tool kit Thermo Fisher Scientific has innovative Thermo Scientific™ BioLC columns for each step of your therapeutic protein characterization, no matter how challenging your separation. Here is just…

APPLICATION NOTE 21777 Innovator Biosimilar Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate Authors Silvia Millán, Anne Trappe, Amy Farrell, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing…