Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies

APPLICATION NOTE 21777 Innovator Biosimilar Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate Authors Silvia Millán, Anne Trappe, Amy Farrell, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing…

APPLICATION NOTE 21684 K KK Using the NISTmAb reference standard to demonstrate a simple approach to charge variant analysis Authors Silvia Millán, Amy Farrell, and Jonathan Bones Characterisation and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…

BioLC columns Connected chromatography solutions BioLC columns and accessories Introduction Your complete tool kit Thermo Fisher Scientific has innovative Thermo Scientific™ BioLC columns for each step of your therapeutic protein characterization, no matter how challenging your separation. Here is just…

Shanhua Lin and Chris Pohl, Thermo Fisher Scientific, Sunnyvale, CA, USA Key Words Rituxan, rituximab, Herceptin, trastuzumab, Humira, adalimumab, Avastin, bevacizumab, CX-1 pH Gradient Buffer Kit, MAbPac SCX-10, mAb charge variant analysis Goal To develop a high-resolution charge variant analysis…