Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-MetaSite and WebMetabase

ION MOBILITY-ENABLED METABOLITE IDENTIFICATION OF TIENILIC ACID AND TIENILIC ACID ISOMER Lauren Mullin1, Giorgis Isaac1, Ian Wilson2, Gordon Murray3, Nathan Anderson1, Robert Plumb1 1 Waters Corporation, 34 Maple St, Milford, MA 01757 Computational and Systems Medicine, Imperial College, London UK…

[ APPLICATION NOTE ] Somatostatin Analogue Catabolite Screening and Identification Using Vion IMS QTof with WebMetabase Mark D. Wrona, 1 Jayne M. Kirk, 4 Ismael Zamora, 2 Tatiana Radchenko, 2 Anna Escola, 3 Antoni Riera, 3 Russell J. Mortishire-Smith4 Waters…

[ APPLICATION NOTE ] Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, and Product Ion Confirmation Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ Ability to screen metabolism from The incorporation of unnatural amino acids,…

ROUTINE METABOLITE IDENTIFICATION FOR COMPLEX PEPTIDES BASED ON IMS ENABLED QTOF DIA DATA ACQUISITION AND MASS-METASITE DATA PROCESSING Authors: Yun W. Alelyunas, Nathan Anderson, Mark D. Wrona Affiliations: Waters Corporation, Milford, MA, USA INTRODUCTION In therapeutic peptide drug discovery and…