Quantitative Analysis and Determination of Molecular Weight of siRNA Type Oligonucleotides by LCMS™-8060

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

Application News No. C215 LC-MS Determination of Molecular Mass and Quantification of Oligonucleotide Therapeutics Using Quadrupole Time-of-Flight Mass Spectrometer LCMS™-9030  Overview Oligonucleotide therapeutics are synthetic oligonucleotides that demonstrate their medical efficacy through binding to target genes or target proteins…

Application News No. C231 Liquid Chromatography Mass Spectrometry Verification of Quantitativity and Confirmation of Molecular Weight of Oligonucleotide therapeutics Using LCMS™-8060 „ Overview „ Sample Oligonucleotide therapeutics are synthetic oligonucleotides which demonstrate medical efficacy by bonding with target genes or…

WP 459 Qualification and Quantitation of Phosphorothioate Oligonucleotides Using a Quadrupole-Time-of-Flight Mass Spectrometer Noriko Kato, Yusuke Inohana, Tairo Ogura, Masaki Yamada, Toshiya Matsubara Shimadzu Corporation. 1, Nishinokyo-Kuwabaracho Nakagyo-ku, Kyoto 604–8511, Japan 3. Methods 1. Overview The purpose of this study…