Determination of Molecular Mass and Quantification of Oligonucleotide Therapeutics Using Quadrupole Time-of-Flight Mass Spectrometer LCMS™-9030

WP 459 Qualification and Quantitation of Phosphorothioate Oligonucleotides Using a Quadrupole-Time-of-Flight Mass Spectrometer Noriko Kato, Yusuke Inohana, Tairo Ogura, Masaki Yamada, Toshiya Matsubara Shimadzu Corporation. 1, Nishinokyo-Kuwabaracho Nakagyo-ku, Kyoto 604–8511, Japan 3. Methods 1. Overview The purpose of this study…

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

TP-511 Accelerating Oligonucleotide Research Using Novel Bioinert LC, QTOF and TQ LC-MS Mridul Mandal, Brian Domanski, Xiaomeng Xia, Nivesh Mittal Shimadzu Scientific Instruments, Columbia, MD Overview  Nucleic acid drugs offer a new avenue for treating a wide range of…

Application News No. C231 Liquid Chromatography Mass Spectrometry Verification of Quantitativity and Confirmation of Molecular Weight of Oligonucleotide therapeutics Using LCMS™-8060 „ Overview „ Sample Oligonucleotide therapeutics are synthetic oligonucleotides which demonstrate medical efficacy by bonding with target genes or…