Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 2- Denaturing and Non-denaturing Analysis of siRNA Payload

Comprehensive LC-MS Analytical Assays for Antibody-Oligonucleotide Conjugate (AOC) and siRNA Linker-Payload Characterization Samantha Ippoliti1; Brad Williams1; Ying Qing Yu1; Connor Brandenburg; Tara MacCulloch; Michelle Chen2; Sophia Kenrick2 1 Waters Corporation, Milford, MA; 2Waters Corporation, Goleta, California INTRODUCTION METHODS Antibody-oligo conjugates…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 3Partial and Complete AOC Conjugation Site Determination Samantha Ippoliti, Ying Qing Yu Waters Corporation, United States Note: This is the third application note in a three-part series on AOC characterization.…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 1- OAR Analysis and Conjugation Process Monitoring Samantha Ippoliti, Ying Qing Yu, Connor Brandenburg, Tara MacCulloch, Michelle Chen Waters Corporation, United States Note: This is the first application note in…

Application Note Characterization and Sequencing of Duplex siRNA Using the BioAccord™ LC-MS System and Vion IMS QTof Mass Spectrometer in Combination With the waters_connect™ CONFIRM Sequence App Rebecca Hirschberger, Michael Rühl, Jonathan Fox, Ying Qing Yu, Scott J. Berger BioSpring,…