Detection and identification of isotope-labeled glutathionetrapped reactive drug metabolites

Pharma and biopharma Accelerating metabolite identification with mass spectrometry Contents 1. Why is metabolite identification critical for drug discovery? Next page 3 1.1. How to perform metabolite identification in drug discovery? 5 1.2. Why is HRAM MS advantageous in metabolite…

Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUITY UPLC I-Class, Xevo G2-S QTof, and UNIFI Yun W. Alelyunas, Mark D. Wrona, and Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C AT…

Search for What’s Missing: Unknown Compound Characterization Using LC-MS Kate Comstock Sr. Marketing Specialist, Pharma/Biopharma Marketing The world leader in serving science Small Molecule Structure Analysis Small molecule structure analysis encompasses broad applications: Pharmaceutical, metabolomics, food & environmental, clinical, forensic,…

APPLICATION NOTE 65953 Confident drug metabolite identification using an intelligent data acquisition and processing workflow Authors: Kate Comstock, Min Du, Thermo Fisher Scientific, San Jose, CA, USA; Min Jiang, Amgen, South San Francisco, CA, USA Keywords: High-Resolution Accurate Mass (HRAM),…