Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUIT Y UPLC I-Class, Xevo G2-S QTof, and UNIFI

Rapid Metabolite Tof Screening, Structure Elucidation and Clearance Estimates Using Informatics-HRMS Approaches AAPS Poster # W4297, Wednesday 9:30-12:30 Yun W. Alelyunas, Mark D. Wrona, and Paul Rainville Purpose: Phase I Examples Glyburide Waters Corporation, Milford, Massachusetts, USA Buspirone Verapamil Demonstrate…

A P P LICAT ION SOLUT IONS FO R M ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA…

Technical note | 003277 Software Detection and identification of isotope-labeled glutathionetrapped reactive drug metabolites A streamlined solution using the Orbitrap Exploris 240 MS and Compound Discoverer software Authors Application benefits Zhixin Miao1, Allison Schmittou1, John Ulrich1, • Accomplish high-throughput metabolites…

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…