A Software Workflow Using Wide Mass Range Single Quadrupole Mass Spectrometry Data Stream Applied to Oligonucleotides Confirmation

Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening Kosuke Uchiyama1, Noriko Kato1, Qiuyi Wang1, Simon Ashton2, Neil Loftus2, Risa Suzuki1, 3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu Scientific Instruments, Inc., Columbia, Maryland…

Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques 1 2 2 3 3 3 3 Nishi Rochelle ; Neil J Loftus ; Simon Ashton ; Kosuke Uchiyama ; Risa Suzuki ; Takashi Nishikaze ; Yuka Fujito…

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

MP 534 Practical LC–MS Workflows for siRNA and sgRNA Characterization Using a Single-Quadrupole Mass Spectrometer Vikki Johnson1, Kathleen Luo1, Risa Suzuki1,2, Atsuhiko Toyama1,2, Jeff Dahl1, Kosuke Uchiyama2, Toshiya Matsubara1 (1) Shimadzu Scientific Instruments, Columbia, MD. (2) Shimadzu Corporation, Kyoto, Japan.…