Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

A Software Workflow Using Wide Mass Range Single Quadrupole Mass Spectrometry Data Stream Applied to Oligonucleotides Confirmation Risa Suzuki1, 2, Kosuke Uchiyama2, Noriko Kato2, Yuka Fujito2, Jeffery Dahl1, Simon Ashton3, Neil Loftus3, Atsuhiko Toyama2, 4 1Shimadzu Scientific Instruments, Inc., Columbia,…

Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening Kosuke Uchiyama1, Noriko Kato1, Qiuyi Wang1, Simon Ashton2, Neil Loftus2, Risa Suzuki1, 3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu Scientific Instruments, Inc., Columbia, Maryland…

Developing a regulatory compliant solution for nominal and accurate mass LC-MS spectrometry analysis in oligonucleotide therapeutics 1 1 1 1 2 2 3 Kosuke Uchiyama ; Risa Suzuki ; Noriko Kato ; Yuka Fujito ; Neil J Loftus ; Simon…