Characterization of Adeno-Associated Virus (AAV) Capsid Proteins with Liquid Chromatography Mass Spectrometry (LC-MS) Based Peptide Mapping and Post Translational Modification (PTMs) Analysis

Application Note Pharma & Biopharma Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies, Inc., Lexington, MA, USA Roy Hegedus and Norman Garceau Lake Pharma, Worcester, MA, USA…

Poster Reprint ASMS 2020 ThP 466 Purity and Identity Characterization of AdenoAssociated Virus Capsid Particles by Intact and BottomUp Based Liquid Chromatography-Mass Spectrometry Methods Wendi A. Hale1, Dominique Garceau2, Tristan Cano2, Caitlin Jaeger2, Roy Hegedus2, William Hermans2, Norman Garceau2, Christopher…

APPLICATION NOTE 000242 Adeno-associated virus capsid protein characterization and host cell protein profiling using micro-flow UHPLC-Orbitrap MS Authors: Reiko Kiyonami1, Jennifer Sutton1, Katy Irvin2, Ken Cook3, Estee Toole4, Min Du5 Thermo Fisher Scientific, San Jose, CA; 2 Thermo Fisher Scientific,…

[ APPLICATION NOTE ] Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS Ximo Zhang, Stephan Koza, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION An optimized LC-MS solution for…