Purity and Identity Characterization of Adeno-Associated Virus Capsid Particles by Intact and Bottom-Up Based Liquid Chromatography-Mass Spectrometry Methods

Application Note Pharma & Biopharma Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies, Inc., Lexington, MA, USA Roy Hegedus and Norman Garceau Lake Pharma, Worcester, MA, USA…

Application Note Biopharma/Pharma Adeno-Associated Virus Characterization with Agilent 6545XT AdvanceBio LC/Q-TOF and Protein Metrics Byos Software Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies Inc. Lexington, MA, USA Michelle English Protein Metrics Cupertino, CA, USA Abstract This application…

Application Note LC/MS of Intact Adeno-Associated Virus Capsid Proteins for Rapid Confirmation of Product Identity Author Brian Liau Agilent Technologies, Inc. Introduction Adeno-associated viruses (AAVs) are a promising new class of biotherapeutic capable of treating a host of rare and…

Poster Reprint ASMS 2021 Poster number WP259 Comprehensive Adeno-Associated Virus Critical Quality Attribute Analysis with Liquid Chromatography-Mass Spectrometry Wendi A. Hale1, Michelle English2, Lawrie Veale2, St John Skilton2, Christopher M. Colangelo1 1Agilent, Lexington, MA 2Protein Metrics, Cupertino, CA Introduction Adeno-associated…