Multi-Reflecting Time of Flight-MS: A Novel Technology for In-depth mAb Subunit Characterization

Application Note Advanced Monoclonal Antibody Peptide Mapping Using Multi-Reflecting TOF MS Technology Jonathan Fox, Ying Qing Yu, Scott J. Berger, Nick Pittman Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract Peptide mapping…

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…

Application Note Advanced Oligonucleotide Characterization Using Multi-Reflecting Time-of-Flight Technology Jonathan Fox1, Ying Qing Yu1, Scott J Berger1, Nick Pittman1 1 Waters corporation, United States Published on May 02, 2025 Abstract LC-MS has become a widely used analytical tool for oligonucleotide…

MEETING DEMANDS FOR IMPROVED MS PERFORMANCE TO SUPPORT DEEPER PRODUCT LC-MS CHARACTERIZATION WITH MULTI-REFLECTING TOF MS TECHNOLOGY Jonathan Fox1, Scott Berger2, Nick Pittman1, Ying Qing Yu2 1Waters Corporation, Wilmslow, Cheshire, UK, 2Waters Corporation, 34 Maple Street, Milford MA, USA. INTRODUCTION…