Quantitative Bioanalysis of Oligonucleotides Using a 6495D Triple Quadrupole LC/MS System Combined with an Automated SPE Workstation

Application Note Biopharma Quantitative Analysis of Nitrosamine Impurities in Synthetic Oligonucleotides Using the Agilent 6495D triple quadrupole LC/MS system Author Abstract Yulan Bian Agilent Technologies, Inc. Nitrosamines are genotoxic impurities of significant concern in pharmaceuticals due to their carcinogenic potential.…

Poster Reprint ASMS 2024 Poster number MP 095 Sensitive Bioanalysis Method for Antisense Oligonucleotides using LC-MS/MS Lee Bertram Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Antisense oligonucleotides (ASOs) have emerged as powerful and versatile therapies in recent years with…

FP 605 Selective and sensitive method for estimation of liraglutide in human plasma using LCMS-8060 Chaitanya Krishna1, Avinash Gaikwad1, Yogesh Arote1, Sujit Patil1, Pratap Rasam2 , Jitendra Kelkar2 1 ADC - Shimadzu Analytical (India) Pvt. Ltd., Nerul, Navi Mumbai-400706, Maharashtra,…

BIOANALYTICAL QUANTIFICATION OF A LIPID CONJUGATED ANTI-SENSE OLIGONUCLEOTIDE ON A HRMS SYSTEM Authors: Nikunj Tanna, Joe Fredette and Mary Trudeau Affiliations INTRODUCTION METHODS SPE METHOD OPTIMIZATION Oligonucleotide therapeutics (ONTs) are a key focus area for many drug developers today given…