Dye Harder with UNcle: Measure Thermal Stability with SYPRO

APPLICATION NOTE Uncle stays hot for proteins with isothermal apps Introduction Testing the isothermal stability of proteins at high-throughput as early as candidate screening is the fastest way to see which ones would fail long-term storage trials. Unfolding and aggregation…

Tech Note Meet Our Uncle: 12 Stability Applications on One Platform Uncle is an all-in-one stability platform that enables twelve different applications with one instrument. Fluorescence, static light scattering (SLS) and dynamic light scattering (DLS) detec­ tion methods are used…

Application Note DNA leaks before capsids pop: AAV thermal stability on Uncle Introduction Characterizing viral stability for gene therapies using adeno-associated virus (AAV) vectors is a complex task and requires understanding behaviors of whole viral particles, viral genomes, and capsid…

Application Note See it all with Uncle's full-spectrum analysis Introduction Measuring thermal stability by pairing heat-induced denaturation with fluorescence detection is a well-established method to optimize stability and formulation for biologics. While in most cases it’s preferable to use label-free…