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APPLICATION NOTE Uncle stays hot for proteins with isothermal apps Introduction Testing the isothermal stability of proteins at high-throughput as early as candidate screening is the fastest way to see which ones would fail long-term storage trials. Unfolding and aggregation…

Application Note Breeze through membrane protein stability with Uncle Introduction Membrane proteins are some of the most important and common drug targets in medicine. Mutated membrane proteins cause disease and are biomarkers for cancers, viral and bacterial membrane proteins are…

Application Note DNA leaks before capsids pop: AAV thermal stability on Uncle Introduction Characterizing viral stability for gene therapies using adeno-associated virus (AAV) vectors is a complex task and requires understanding behaviors of whole viral particles, viral genomes, and capsid…

Tech Note Meet Our Uncle: 12 Stability Applications on One Platform Uncle is an all-in-one stability platform that enables twelve different applications with one instrument. Fluorescence, static light scattering (SLS) and dynamic light scattering (DLS) detec­ tion methods are used…