High-throughput protein stability screens with Aunty

APPLICATION NOTE Meet Aunty – the Queen of protein stability Introduction Aunty is the fastest, highest throughput protein stability platform on the planet (Figure 1). Other stability methods each have their drawbacks: some are slow, others don’t give the full…

Application Note Multi-day biologics stability experiments with Uncle Introduction 300 Thermal ramp stability measurements (Tm and Tagg) are well-established methods to quickly rank order the stability of protein constructs and formulations. Ranking may be more difficult if Tm or Tagg…

APPLICATION NOTE Sail through formulation screening on Uncle and Honeybun A Introduction Monoclonal antibodies (mAbs) and other biologics experience all kinds of stresses and need to be stable in lots of different environments and at a range of concentrations. High…

APPLICATION NOTE Conquer ADC stability characterization with Aunty Introduction Conjugating potent cytotoxic payloads to monoclonal antibodies results in powerful anti-cancer therapeutics, but the resulting antibody-drug conjugates (ADCs) have unique stability challenges.1 Attaching a hydrophobic small molecule drug to a hydrophilic…