Sail through formulation screening on Uncle and Honeybun

APPLICATION NOTE Speed up and simplify formulation screens with Big Tuna and Stunner Introduction A Developability and formulation screening of biologics is labor-intensive and time-consuming. Buffer exchange is part of the problem because conventional methods are prone to inconsistency, and…

APPLICATION NOTE Meet Aunty – the Queen of protein stability Introduction Aunty is the fastest, highest throughput protein stability platform on the planet (Figure 1). Other stability methods each have their drawbacks: some are slow, others don’t give the full…

APPLICATION NOTE Conquer ADC stability characterization with Aunty Introduction Conjugating potent cytotoxic payloads to monoclonal antibodies results in powerful anti-cancer therapeutics, but the resulting antibody-drug conjugates (ADCs) have unique stability challenges.1 Attaching a hydrophobic small molecule drug to a hydrophilic…

APPLICATION NOTE Uncle stays hot for proteins with isothermal apps Introduction Testing the isothermal stability of proteins at high-throughput as early as candidate screening is the fastest way to see which ones would fail long-term storage trials. Unfolding and aggregation…