Accurate and consistent analysis of poly(A) tails of mRNA therapeutics on a UHPLC-HRAM-MS platform

A simple and robust LC-MS method for determination of poly(A) tail length using the Orbitrap Exploris MS systems Hao Yang, Robert Ross, Keeley Murphy, Yi Zhang, Min Du, Thermo Fisher Scientific, San Jose, CA, USA INTRODUCTION The introduction of effective…

Application note | 001183 Biopharma Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software Authors Application benefits Robert L. Ross1, Jenny England2, Rhonda • Confident identification and sequence confirmation of polyadenylated tails in synthetic…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…

Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms Hao Yang1; Keeley Murphy2; Jennifer Sutton1; Ken Cook3;Cheryl Rhodick3; Tufail Bashir3; Angela Criscuolo3; Tabiwang N. Arrey4; Catharina Crone4; Min Du2 1Thermo Fisher Scientific, San Jose, CA, United…