Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms

Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…

Mass spectrometry Perfect fit Orbitrap Exploris MX mass detector Fit for purpose mass detection High-quality mass information offers significant advantages in accelerating biopharmaceutical late-stage development, commercialization, manufacturing, and quality control (QC). This information must be easily and reliably obtained, day…

Oligonucleotides Capillary flow ion pair reversed-phase separation for very sensitive oligonucleotide LC-HRMS analysis and characterisation Ulrik H. Mistarz1, Shanhua Lin2, Shane L. Bechler2, Brandon H. Robson2, Ken Cook3 1) Thermo Fisher Scientific, Allerød, Denmark, 2) Thermo Fisher Scientific, Sunnyvale, CA…

Biopharma By your side Accelerating biotherapeutic development Enabling every step of your biotherapeutic development We equip you to overcome today’s and tomorrow’s challenges with tools and expertise to advance life-changing biotherapeutics to market faster than ever before. Your molecules are…