Determining the Kinetics of Covalent Thrombin-Antithrombin Association

Light Scattering for the Masses ® Does Antithrombin III Block the Action of a Monoclonal Anti-Thrombin Antibody? Summary Multi-angle light scattering (MALS) is a powerful tool for quantifying multiple types of protein-protein interactions. In a previous application note, we described…

Light Scattering for the Masses ® Measuring the Interaction Between Thrombin-α and an Anti-Thrombin Antibody Summary Antibody-antigen binding, hormone-receptor interactions, and many other common biomolecular interactions occur at stoichiometries other than 1:1. The Wyatt Calypso system utilizes composition-gradient multi-angle light…

Volume 28, Number 1 Technical Article by Dan Some and Amy Hanlon Characterizing Protein–Protein Interactions Via Static Light Scattering: Inhibition Kinetics and Dissociation Q uantification of the kinetic rates of protein association, dissociation, and aggregation is an essential factor in…

W H I T E PA P E R WP3001: SEC-MALS and CG-MALS: Complementary Techniques to Characterize Protein-DNA Complexes Sophia Kenrick, Ph.D., Waters | Wyatt Technology Summary Interactions between proteins and nucleic acids often result in binding stoichiometries greater than…