Investigating The Relationship Between Off Target Pharmacology & The DMPK of Methapyrilene Using Lipidomics And MS Imaging

APPLICATION OF TARGETED LIPIDOMICS TO DETERMINE CHANGES IN THE PLASMA LIPIDOME OF MALE RATS FOLLOWING REPEAT ORAL ADMINISTRATION OF METHAPYRILENE Authors: Roy Martin1, Anthony Midey1, Ian D Wilson2, Robert S Plumb1 Affiliations: 1 Waters Corporation, Milford, MA, USA, 2 Imperial…

TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUGINDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT Anthony Midey,1 Emmanuelle Claude,2 Lisa Reid,2 Bindesh Shrestha,1 Steven K Lai,1 Ian D Wilson,3 Robert S Plumb,1 and Roy Martin1…

LIPIDOMIC AND DESI IMAGING STUDY OF MOUSE LIVER DOSED WITH A TYROSINE KINASE INHIBITING DRUG Nyasha Munjoma 1 , Giorgis Isaac 2 , Mark Towers 1 , Emmanuelle Claude 1 , Ian D Wilson 3 , Lee A. Gethings 1…

Application Note LipidQuan™: A Robust LC-MS/MS Methodology for Rapidly Profiling the Lipidome of Liver Tissue Following Metabolism of the Drug Gefitinib Nyasha Munjoma, I.D. Wilson, Lee A. Gethings, Robert S. Plumb Waters Corporation For research use only. Not for use…