An improved EasyPep sample preparation method for enrichment and quantitation of host cell proteins

Enhanced HCP quantitation LC-MS/MS workflow solution using a MS sample prep method Jae Choi1, Reiko Kiyonami2, Min Du2, Sarah Driscoll3, Km Shams Ud Doha3, Nikki Jarrett1, Kay Opperman1, Ryan Bomgarden1, Bhavin Patel1; 1Thermo Fisher Scientific, Rockford, IL, 2Thermo Fisher Scientific,…

High-sensitivity Host Cell Protein (HCP) analysis on a new Orbitrap Excedion Pro BioPharma hybrid mass spectrometer with optimized sample preparation Xiaoxi Zhang1, Reiko Kiyonami2, Jae Choi3, Bhavin Patel3, Cong Wang4, Peter Krueger4, Heiner Koch4, Min Du2. 1 Thermo Fisher Scientific,…

Increasing sensitivity of high throughput host cell protein analysis on a novel highresolution accurate mass platform Eugen Damoc1; Tabiwang N. Arrey1; Anna Pashkova1; Eduard Denisov1; Kai Scheffler2; Kristina Srzentić3 1Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany; 2Thermo Fisher Scientific, Germering,…

APPLICATION NOTE 73412 Residual host cell protein analysis of NISTmAb: From simplified sample preparation to reliable results Authors: Amy Claydon, Phil Widdowson, and Andrew Williamson Thermo Fisher Scientific, Hemel Hempstead, UK Keywords: Host cell protein assay, HCP, monoclonal antibody, mAb,…