Hydrophobic Interaction Chromatography- Native Mode Separation of Bio-Therapeutic Workflows

Agilent-NISTmAb Intact Analysis Using Hydrophobic Interaction Agilent BioHPLC Columns Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test includes aggregate…

Yingyu Li1, Sandeep Kondaveeti1, Greg Staples2, Andy Coffey3, Wu Cheni1 Intact Analysis of Biopharmaceuticals by Hydrophobic Interaction/Reversed Phase 2D-LC/MS System 1. Agilent Technologies, Inc., Wilmington, DE USA 2. Agilent Technologies, Inc., Santa Clara, CA USA, 3. Agilent Technologies, Church Stretton,…

Application Note Biologics Research AdvanceBio HIC: a Hydrophobic HPLC Column for Monoclonal Antibody (mAb) Variant Analysis Using the Agilent 1260 Infinity II Bio-Inert LC Authors Andrew Coffey and Sandeep Kondaveeti Agilent Technologies, Inc. Abstract This Application Note describes the separation…

Application Note Biologics Development An AdvanceBio HIC Column for Drug‑to-Antibody Ratio (DAR) Analysis of Antibody Drug Conjugates (ADCs) Using the Agilent 1260 Infinity II Bio-Inert LC Author Andrew Coffey and Sandeep Kondaveeti Agilent Technologies, Inc. Abstract This Application Note describes…