Rapid monitoring of the purification process of oligonucleotide impurities using a benchtop MALDI-TOF MS system

High Resolution Mass Spectrometry and LC-UV Data Streams Applied to Characterizing Oligonucleotide Impurities Kosuke Uchiyama1, Noriko Kato1, Takeshi Nomura1, Hiroyuki Yasuda1, Simon Ashton2, Richard Price2, Helen Jose2, Neil Loftus2, Kiyoshi Kakiya3, Kazutoshi Kishi3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu…

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques 1 2 2 3 3 3 3 Nishi Rochelle ; Neil J Loftus ; Simon Ashton ; Kosuke Uchiyama ; Risa Suzuki ; Takashi Nishikaze ; Yuka Fujito…

Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening Kosuke Uchiyama1, Noriko Kato1, Qiuyi Wang1, Simon Ashton2, Neil Loftus2, Risa Suzuki1, 3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu Scientific Instruments, Inc., Columbia, Maryland…