Analysis of Monoclonal Antibodies and Antibody-Drug Conjugates Using New Hydrophobic Interaction Chromatography (HIC) Columns

Thermo Scientific MAbPac HIC Columns Novel Hydrophobic Interaction HPLC Columns Designed for Monoclonal Antibody Analysis Introduction The Thermo Scientific™ MAbPac™ HIC column family is designed for separations of monoclonal antibodies (mAbs) and related biologics by hydrophobic interaction chromatography (HIC). Their…

C H R O M ATO G R A P H Y P rod u ct S p ecif ica t ions MAbPac HIC-Butyl Column High resolution HIC column for monoclonal antibody analysis The Thermo Scientific™ MAbPac™ HIC-Butyl column is…

See your protein therapeutics in high resolution Bio LC Columns Contents 2 Introduction to monoclonal antibody (mAb) characterization 3 Affinity titer determination 4 Aggregate separation 5 Charge variant analysis 6 Oxidation variant analysis 11 Antibody drug conjugates (ADCs) analysis 12…

Julia Baek and Xiaodong Liu, Thermo Fisher Scientific, Sunnyvale, CA, USA Appli cat i on N ote 2 1 0 7 9 High-Resolution Separation of Cysteine-Linked Antibody-Drug Conjugate Mimics Using Hydrophobic Interaction Chromatography Key Words Hydrophobic interaction chromatography, HIC, monoclonal…