A high-sensitivity high-throughput LCMS platform for single-cell proteomics and low sample amount analysis

Proteomics Balancing sensitivity and throughput in single-cell proteomics using low-nanoflow LC-MS Runsheng Zheng1; Manuel Matzinger2; Rupert Mayer2; Alec Valenta1; Tabiwang N Arrey3; Xuefei Sun4; Christopher Pynn1; Ece Aydin1; Wim Decrop1; Dominic Hoch5; Martin Samonig1; Karl Mechtler2 1Thermo Fisher Scientific, Germering,…

Technical note | 001939 Proteomics High-sensitivity low-nano flow LC-MS methods for high-throughput sample-limited proteomics Authors Goal Runsheng Zheng, Alec Valenta, Demonstrate high-throughput and high-sensitivity nano-flow LC-MS methods using a Christopher Pynn, Ece Aydin, 50 μm i.d. column operated at 100…

Balancing sensitivity and throughput for the analysis of limited sample amounts in proteomics with ultra-low nano-flow LC-MS Runsheng Zheng1; Sun Xuefei2; Karel Stejskal3; Manuel Matzinger4; Christopher Pynn5; Karl Mechtler3, 4, 6; Oleksandr Boychenko1 1Thermo Fisher Scientific, Germering, Germany; 2Thermo Fisher…

Technical note | 003335 Omics Maximizing sample throughput and sensitivity in nano- and capillary-LC-MS Harnessing a tandem direct injection workflow and a dual spray ion source Authors Goal Runsheng Zheng , Martin Rendl , Alec C. Valenta2, Christopher Pynn1, Till…