Synthetic modified oligonucleotides analysis using a matrix-assisted laser desorption/ionization digital-ion-trap mass spectrometer (MALDI-DIT-MS)

WP 568 Morpholino antisense oligonucleotides analyses using a compact matrix-assisted laser-desorption/ionization digital-ion-trap mass spectrometer (MALDI-DIT-MS) Yuko Fukuyama, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka Shimadzu Corporation, Koichi Tanaka Mass Spectrometry Research Laboratory, Kyoto, Japan. Abstract: ◆ Morpholino antisense oligonucleotides were analyzed…

MALDI-DIT-MS Application News Oligonucleotide Analysis Using the Compact MALDImini™-1 MALDI Digital Ion Trap Mass Spectrometer Yuko Fukuyama User Benefits  Enables molecular weight analysis and sequence analysis of oligonucleotides, including modification sites.  MSn enables reliable end sequence analysis. …

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…