Reduce Overall Cost, Time, and Environmental Impact by Scaling Down Using Comparable L/dp

CONSIDERATIONS FOR DEVELOPING A GREENER CHROMATOGRAPHIC METHOD Nicholas Santiago, Bonnie A. Alden, Kenneth D. Berthelette, Kimberly Haynes Waters Corporation, Milford, MA, USA 01757 INTRODUCTION RESULTS DISCUSSION Method development for reversed-phase high-performance liquid chromatography (HPLC) separations has traditionally been conducted using…

Application Note Improving Sample Throughput of HPLC Methods Using CORTECS 5 µm Columns Kenneth Berthelette, Maureen DeLoffi, Thomas H Walter Waters Corporation, United States Published on October 28, 2025 Abstract Validated HPLC methods are prime targets for systematic improvements like…

INCREASING THE THROUGHPUT OF CANNABINOID PROFILING AND POTENCY DETERMINATION USING CHROMATOGRAPHIC GEOMETRIC SCALING PRINCIPLES Catharine E. Layton and Andrew J. Aubin, Waters Corporation, Milford, MA USA CBL-A CBC CBL 0.06 for analysis. Concentrates were prepared similarly with isopropanol used as…

Transferring HPLC Gradient Methods Using CORTECS Solid-Core Particle Columns Jonathan E. Turner, Bonnie A. Alden, Mia Summers, Kenneth Berthelette, and Kenneth J. Fountain Waters Corporation, Milford, MA, USA A P P L I C AT I O N B E…