CERM: CONSIDERATIONS FOR DEVELOPING A GREENER CHROMATOGRAPHIC METHOD

Application Note Greener, Lower Cost Organic Mobile Phase Solvents for the LC-MS Analysis of Intact Biotherapeutic Proteins Henry Shion, Ying Qing Yu Waters Corporation Abstract This application note presents on the recent trend replacing acetonitrile (Class II Toxicity) with greener…

Guide to Size-Exclusion Chromatography (SEC) of mAb Aggregates, Monomers, and Fragments 1 Table of Contents I. Introduction II. Importance of Developing a Robust LC-based SEC Method a. Choosing the Appropriate Protein BEH SEC Column b. Method Development III. Considerations When…

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…

ApplicAtion SolutionS for BiophArmAceuticAlS A Focus on Protein Therapeutics Introduction: Key Challenges in Biopharmaceutical Characterization .............................................................................................5 7 PROTEIN mass aNalysIs comprehensive and routine characterization of proteins and peptides by lc/mS and lc/mS e ...............................................................9 characterization of an igG1 monoclonal Antibody…