Top-down characterization of native monoclonal antibodies obtained with electron capture dissociation on Q-TOF instruments

Poster Reprint ASMS 2024 Poster number TP 150 Top-down Characterization of Intact Proteins via On-line Charge-stripping and Electron Capture Dissociation Yury. V. Vasil’ev, Michael C. Hare, Ruwan T. Kurulugama, Joseph C. Meeuwsen, Bill Russ Agilent Technologies, Inc., USA Introduction Top-down…

Application Note Biopharma Top-Down Sequence Analysis of Intact Proteins Using an Agilent AdvanceBio 6545XT LC/Q-TOF with ExD Authors Rachel Franklin and Mike Hare Agilent Technologies, Inc. Abstract Detailed proteoform characterization is crucial for understanding disease mode of action (MOA) and…

Poster Reprint ASMS 2024 Poster number ThP 025 Top-Down CDR Sequencing of Native Intact mAbs Through Deconvolution of HC+LC Mixture Spectra Lily E. Miller1; Stephanie Sturgeon2; Yury V. Vasilev2; Rachel Franklin2; Blake Hakkila2; Timothy Djang3; Alex Gavrilenko3; Jhenya Gavrilenko3; Panos…

Poster Reprint ASMS 2024 Poster number MP 645 Combining Microdroplet Reactions with ExD Fragmentation for Fast Characterization of Proteins and Antibody Subunits Thomas E Walker1; Rachel Franklin2; Joseph Meeuwsen2; Jim Lau3 1Agilent Technologies, Lexington, MA 2Agilent Technologies, Corvallis, Oregon 3Agilent…