Top-down Characterization of Intact Proteins via On-line Charge-stripping and Electron Capture Dissociation

Poster Reprint ASMS 2024 Poster number WP 470 High-Efficiency Electron Capture Dissociation of Peptides and Proteins After Collision-Induced Unfolding and Ion Mobility Joseph C. Meeuwsen1, Yury V. Vasilev1, Ruwan T. Kurulugama1, Valery G. Voinov1 1Agilent Technologies, Inc., Santa Clara, CA…

Poster Reprint ASMS 2025 Poster number TP 703 In-Source Charge Reduction Enhances Top-Down Characterization of Denatured Proteins Rachel Franklin1; Yury V. Vasilev1; John Mehl2 1Agilent Technologies, Inc., Corvallis, OR 2Agilent Technologies, Inc., Wilmington, DE Introduction Experimental Denatured proteins often yield…

Poster Reprint ASMS 2026 TP 388 Studying protein and peptide non-covalent complexes with ion mobility and electron capture dissociation mass spectrometry Yury V. Vasil’ev, Rachel Franklin Agilent Technologies, Inc., Corvallis, OR, USA Introduction Peptide/protein non-covalent oligomers Peptide/protein non-covalent oligomers are…

Application Note Biopharma Top-Down Sequence Analysis of Intact Proteins Using an Agilent AdvanceBio 6545XT LC/Q-TOF with ExD Authors Rachel Franklin and Mike Hare Agilent Technologies, Inc. Abstract Detailed proteoform characterization is crucial for understanding disease mode of action (MOA) and…