Considerations and Impact of Extra-Column Volume on the Analysis and Scaling of a HPLC Separation

[ APPLICATION NOTE ] Scaling USP Methods to Smaller Particle Columns on the Alliance HPLC System Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Reduce run time and solvent…

[ APPLICATION NOTE ] Demonstration of the USP Quetiapine Fumarate Impurities Method Across a Wide Range of Liquid Chromatographic Systems Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ The USP…

[ APPLICATION NOTE ] Gradient Method Scaling for Life Cycle Management of a USP Impurities Method Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ The Waters™ Columns Calculator enables Pharmaceutical…

[ APPLICATION NOTE ] Scaling of a USP Assay for Quetiapine Fumarate Across Different Liquid Chromatographic Systems Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ The Waters Column Calculator enables…