Scaling USP Methods to Smaller Particle Columns on the Alliance HPLC System

Application Note Taking Advantage of 12k psi Pressure Capabilities for Modernizing USP Methods on the Alliance™ iS HPLC System Amanda B. Dlugasch, Paula Hong Waters Corporation, United States Published on August 19, 2025 Abstract Pharmaceutical companies frequently use compendial high…

[ APPLICATION NOTE ] Gradient Method Scaling for Life Cycle Management of a USP Impurities Method Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ The Waters™ Columns Calculator enables Pharmaceutical…

[ APPLICATION NOTE ] Scaling of a USP Assay for Quetiapine Fumarate Across Different Liquid Chromatographic Systems Amanda B. Dlugasch, Jennifer Simeone, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ The Waters Column Calculator enables…

EMPLOYING MODERN LIQUID CHROMATOGRAPHY TECHNOLOGY TO SCALE A USP GRADIENT METHOD ON A SINGLE LIQUID CHROMATOGRAPHIC SYSTEM Amanda B. Dlugasch, Jennifer Simeone, Paula Hong and Zhimin Li Waters, Corporation. Milford, Massachusetts, USA INTRODUCTION The continual development and modernization of pharmaceutical…