Improvements to ProSightPD nodes in the Thermo Scientific Proteome Discoverer Software Framework

proteins on a proteomics scale is challenging and requires significant method optimization of front–end separation, instrument parameters and data analysis. In this study, we developed a general RP-LC-MS method for intact/ top-down analysis on an Orbitrap Fusion mass spectrometer using…

Quantitative Top-Down Proteomics of Human Tears Reveals Proteoform Changes Related to Age Mick Greer1, Daniel Lopez-Ferrer2, Romain Huguet2, Peter Verhaert3, Greg Foster4, Vlad Zabrouskov2, Andreas Huhmer2, Peter Raus5, Ken Durbin6, Joe Greer6, Ryan Fellers6, Rich Leduc6 1 ThermoFisher Scientific, Austin,…

The intelligent protein informatics platform Thermo Scientific Proteome Discoverer software Transform proteomics mass spectrometry data into insights Thermo Scientific™ Proteome Discoverer™ software enables comprehensive proteomics data processing workflows empowered by artificial intelligence. • Powerful and flexible framework: Optimized analysis for…

High-throughput Top-down FAIMS Data Analysis with ProSightPD Nodes in Proteome Discoverer Software Mick Greer1, Vincent Gerbasi2, Joseph Greer3, Ryan Fellers3, David Horn4, Romain Huguet4, Susan Abbatiello5, Michael Belford4, Philip Compton2, Kenneth Durbin3, Neil Kelleher2, Richard LeDuc3, Scott Peterman4, Paul Thomas2…