TIDES: INTACT MASS - A VERSATILE SOFTWARE FOR RAPID MASS CONFIRMATION OF OLIGONUCLEOTIDES AND THEIR IMPURITIES

Application Note LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application Catalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing…

Application Note Oligo Mapping of sgRNA Digests: Leveraging Xevo MRT Mass Spectrometer Performance and Streamlining Data Analysis Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters Corporation, Milford, MA, United…

AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…

Application Note A Xevo™ G3-based Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Impurities Detected in Synthetic Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Brad J. Williams, Chris Knowles, Ying Qing Yu Waters Corporation Abstract This study evaluates…