Fast Online Desalting of mAbs Using a Reversed-Phase Desalting Cartridge for LC-MS Analysis

TECHNICAL NOTE Authors: Martin Samonig, Sabrina Patzelt, Martin Rühl, and Remco Swart Thermo Fisher Scientific, Germering, Germany Key words Pre-concentration, trap and elute, desalt, MSPac, MAbPac, monoclonal antibody, mAb, Vanquish, reversed phase, mass spectrometry, Q Exactive, biopharmaceutical, biomolecules, intact protein…

Martin Samonig, Remco Swart Thermo Fisher Scientific, Germering, Germany Appli cat i on N ote 1 1 3 3 SEC-MS with Volatile Buffers for Characterization of Biopharmaceuticals Key Words Monoclonal Antibodies, MAbPac SEC-1, Biocompatible UHPLC, Biotherapeutics Characterization, Biopharma Goal Prove…

Clone Selection Using the Agilent 1290 Infinity Online 2D-LC/MS Solution Application Note Biopharmaceuticals Authors Abstract Ravindra Gudihal and This Application Note describes the Agilent 1290 Infinity online 2D-LC/MS Syed Salman Lateef solution and proof of principle for clone selection and…

Application Note Biologics Efficient Monoclonal Antibody and Antibody Drug Conjugate Desalting Prior to Mass Spectrometry Using AdvanceBio Desalting-RP Cartridges Authors Isabel Vandenheede, Pat Sandra, and Koen Sandra Research Institute for Chromatography (RIC) President Kennedypark 26 B-8500 Kortrijk Anne Blackwell and…