Monoclonal antibody characterization through native Orbitrap mass spectrometry leading to improved sensitivity and elucidation of microheterogeneity

Application note | 003310 Biopharma Monitoring of multiple quality attributes of intact monoclonal antibodies from bioreactors by switchable 2D-LC-MS Authors Application benefits Maria Grübner , Kai Scheffler , 1 1 • Heart-cut 2D-LC with protein A affinity chromatography (ProA) of…

APPLICATION NOTE 21918 Easy, fast and reproducible analysis of host cell protein (HCP) in monoclonal antibody preparations Authors Giorgio Oliviero1, Ken Cook 2, Kai Scheffler3, Florian Füssl1, Jonathan Bones1 1National Institute for Bioprocessing Research and Training, Dublin, Ireland; 2Thermo Fisher…

Application note | 001391 Biopharma Improved and universal inline electrochemical reduction and subunits LC-MS analysis of multiple classes of monoclonal antibodies Authors Application benefits Sara Carillo, Tomos E. Morgan, Hendrik1 1 • Reduced mAb and reduced subunits analysis can be…

Chromatographic Workflows for Biopharmaceutical Characterization Dr. Ken Cook European Bioseparation Sales Support Expert Thermo Fisher Scientific, Hemel Hempstead/Germany The world leader in serving science Fulfilling the Needs of Biotherapeutic Characterization Charge variant screening Peptide mapping Released glycan analysis Aggregate screening…