Refinement of HR Multi-Attribute Method from Sample Preparation to Data Analysis

APPLICATION NOTE 72916 A high-resolution accurate mass multi-attribute method for critical quality attribute monitoring and new peak detection Authors Haichuan Liu1, Royston Quintyn2, John Rontree3 Thermo Fisher Scientific 1 San Jose, CA 2 West Palm Beach, FL 3 Hemel Hempstead,…

Analytical solutions for biopharmaceutical characterization and control Your partner on every step of your journey Together we can address the challenges of biotherapeutic drug development Your molecules are complex Biotherapeutics such as monoclonal antibodies, biosimilars, antibody-drug conjugates, and nucleotide-based therapies…

APPLICATION NOTE 21782 Comparison of alternative approaches to trypsin protein digestion for reproducible and efficient peptide mapping analysis of monoclonal antibodies Authors Silvia Millán-Martín, Craig Jakes, Noemi Dorival-García, Nicola McGillicuddy, Sara Carillo, Amy Farrell, Jonathan Bones National Institute for Bioprocessing…

Customer note | 001731 Biopharmaceuticals Development of a systematic approach for improving tryptic digestion, recovery and chromatographic performance for mAb analysis Addressing missed cleavages and optimizing chromatographic performance of hydrophobic peptides in peptide mapping assays Authors Application benefits Dan B.…