An Ultra High-throughput Plasma Protein Profiling (uHTPPP) Workflow Using a Modified Quadrupole-Orbitrap Mass Spectrometer

Proof of performance Orbitrap Exploris 240 mass spectrometer Plasma profiling–reliable large cohort analysis with a fully automated workflow Summary Here we present an Ultra-High Throughout Plasma Protein Profiling (uHTPPP) workflow (Figure 1), from automated sample preparation to high-resolution, accurate-mass (HRAM)…

APPLICATION NOTE 65952 A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling Authors: Michelle L Dubuke1, Sitara Chauhan1, Sarah Trusiak1, and Emily I. Chen1 1 Thermo Fisher Scientific Precision Medicine…

CASE STUDY 66002 Orbitrap Exploris 240 mass spectrometer delivers significantly increased lab productivity and reproducibility of human plasma proteome profiling from large human cohort studies “For large clinical cohort studies where hundreds of plasma samples are to be analyzed, a…

APPLICATION NOTE 65727 Sampling the human population – ultra-highthroughput plasma protein profiling (uHTPPP) sample preparation for translational proteomics Authors: Sarah Trusiak,1 Sergei Snovida,2 Bhavin Patel,2 Ryan Bomgarden,2 Emily I. Chen,1 1 Thermo Fisher Scientific Precision Medicine Science Center, Cambridge, MA,…