Mass Confirmation and Purity Analysis of PCR Primer and Probe Reagents Using High Sensitivity Ion-pairing LC-MS

Application Note Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with the BioAccord LC-MS System Jennifer M. Nguyen, Siu-Hong Chan, Bijoyita Roy, Martin Gilar, Brett Robb, Weibin Chen, Matthew A. Lauber Waters Corporation, New England Biolabs Inc. Abstract…

Application Note Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatography – Columns and Chemistries Martin Gilar, Nicholas J. Zampa Waters Corporation Need Help? To learn more about how Waters can help you in your efforts against COVID-19,…

[ APPLICATION NOTE ] An Automated Compliance-Ready LC-MS Workflow for Intact Mass Confirmation and Purity Analysis of Oligonucleotides Catalin Doneanu, 1 Jonathan Fox, 2 Emma Harry, 2 Chris Knowles, 3 Ying Qing Yu,1 Joseph Fredette, 1 and Weibin Chen1 1…

Application Note Enhanced Resolution for Longer Oligonucleotide Analytes With a MaxPeak™ Premier Oligonucleotide BEH C18 300 Å Column Balasubrahmanyam Addepalli, Makda Araya, Matthew A. Lauber Waters Corporation Abstract Ion-pairing reversed phase liquid chromatography is widely used to characterize the identity,…