Application Note Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modified Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Emma Harry, Chris Knowles, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation For research use only.…
Application Note HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioAccord System Catalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin Chen Waters Corporation Abstract HILIC chromatography provides a clean, cost-effective…
Application Note Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier Catalin E. Doneanu, Chris Knowles, Jonathan Fox, Emma Harry, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation Abstract This application note demonstrates an automated, compliance-ready LC-MS…
AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…
