Development of Ultra-fast pH-Gradient Ion Exchange Chromatography for the Separation of Monoclonal Antibody Charge Variants

APPLICATION NOTE 21778 Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies Authors Amy Farrell, Craig Jakes, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…

[ APPLICATION NOTE ] Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Method development parameters for cation Charge heterogeneity…

Chromatographic Workflows for Biopharmaceutical Characterization Dr. Ken Cook European Bioseparation Sales Support Expert Thermo Fisher Scientific, Hemel Hempstead/Germany The world leader in serving science Fulfilling the Needs of Biotherapeutic Characterization Charge variant screening Peptide mapping Released glycan analysis Aggregate screening…

APPLICATION NOTE 21777 Innovator Biosimilar Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate Authors Silvia Millán, Anne Trappe, Amy Farrell, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing…